![]() Alterations in metabolic pathways deregulated during obesity and metabolic syndrome could in part explain the disturbances in the epigenetic marks of the AT in these disorders. Thus, the epigenetic landscape emerges as a fineātune regulator of the cellular responses according to the energetic, metabolic and physiological conditions of the cell. We highlight the importance of nutrients and lifestyle in the regulation of the epigenetic mechanisms and how they can impact on AT plasticity and function in obesity and metabolic diseases. Here, we review the role of epigenetics in the onset of obesity and related metabolic disorders, with special focus on AT. Epigenetics includes mechanisms by which the cell can adapt the cellular response to the environmental conditions. These processes can regulate gene expression, chromatin compaction and DNA repair. Epigenetics refers to several processes that add modifications to either the DNA or chromatin architectural proteins (histones). The impairment of adipose tissue (AT) function is partially responsible for the aetiology of these conditions. Obesity and metabolic syndrome are among the most prevalent health problems in developed countries.
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